Publications
Biomaterials, 324:123530 (2026)
Polydopamine nanoparticle-enhanced stem cell spheroid-derived decellularized ECM with antioxidant and tissue adhesive properties for brain repair
Yang PC, Kao YC, Lin YP, Chen GH, Liu SW, Ho CH, Huang SC, Lee PY, Chen L, Huang CC*
Advanced Drug Delivery Reviews, 229:115746 (2026)
Gas-based therapeutics and delivery platforms in cancer immunotherapy
Nguyen VAT, Huang CC*, Chen Y*
Carbohydrate Polymers, 382:125257 (2026)
Repurposing tumor-derived extracellular vesicles with an adhesive carboxymethyl chitosan-based hydrogel for spinal cord injury repair
Wang KL, Hsiao YC, Pan WY, Lin CJ, Huang CC*, Lin YJ*
Biomaterials Advances, 183:214719 (2026)
Lysophosphatidic acid-induced upregulation of exosomal miR-221-3p from corneal stromal cells promotes corneal endothelial healing
Chen HC*, Hsueh YJ, Meir YJ, Lai JY, Huang CC, Lu TT, Cheng CM, Lin SS, Ma HK, Wu WC
Chemical Science, 17:1073-1097 (2026)
Magneto-voltaic activity of single-atom iron on reduced graphene oxide for magneto-catalytic conversion of H2O2 into O2
Chung CW, Huang JY, Liang JG, Iffland L, Dayao LA, Dhanthala Chittibabu DK, Chi CC, Chen JL, Chan TS, Chen CL, Lu YR, Huang CC, Chou HH, Lin ZH, Chen YC, Lu MY, Chen HT*, Apfel UP*, Lai YC*, Lu TT*
Biomaterials, 321:123332 (2025)
Tailoring the therapeutic potential of stem cell spheroid-derived decellularized ECM through post-decellularization BDNF incorporation to enhance brain repair
Kao YC, Yang PC, Lin YP, Chen GH, Liu SW, Ho CH, Huang SC, Lee PY, Chen L, Huang CC*
Biomaterials, 315:122941 (2025)
Implantation of MSC spheroid-derived 3D decellularized ECM enriched with the MSC secretome ameliorates traumatic brain injury and promotes brain repair
Chen GH, Sia KC, Liu SW, Kao YC, Yang PC, Ho CH, Huang SC, Lee PY, Liang MZ, Chen L, Huang CC*
Advanced Healthcare Materials, 14:2401724 (2025)
Injectable glucose-releasing microgels enhance the survival and therapeutic potential of transplanted MSCs under ischemic conditions
Huang CC*, Chang CK, Yang PC, Chiu H, Chen SH, Hsu LW
Stem Cell Research & Therapy, 16:172 (2025)
Assembly of MSCs into a spheroid configuration increases poly(I:C)-mediated TLR3 activation and the immunomodulatory potential of MSCs for alleviating murine colitis
Ho CT, Kao YC, Shyu YM, Wang IC, Liu QX, Liu SW, Huang SC, Chiu H, Hsu LW, Hsu TS*, Hsieh WC*, Huang CC*
Journal of Tissue Engineering, 16 (2025)
Spheroid assembly of mesenchymal stem cells enhances secretome-mediated corneal reinnervation and epithelial repair in a mouse model of experimental dry eye
Liu SW, Tsai MY, Shen YC, Hsueh YJ, Chiu H, Hsu LW, Chen HC*, Huang CC*
JACS Au, 4:1550-1569 (2024)
Mechanistic and kinetic insights into cellular uptake of biomimetic dinitrosyl iron complexes and intracellular delivery of NO for activation of cytoprotective HO-1
Chiu H, Chau FA, Chen YH, Koi RX, Yu CK, Hsieh LH, Shyu YM, Amer TAM, Hsueh YJ, Tsao TY, Shen YJ, Wang YM, Chen HC*, Lu YJ*, Huang CC*, Lu TT*
Bioengineering & Translational Medicine, 9:10635 (2024)
Schwann cells acquire a repair phenotype after assembling into spheroids and show enhanced in vivo therapeutic potential for promoting peripheral nerve repair
Chen SH*, Wang HW, Yang PC, Chen SH, Ho CH, Yang PC, Kao YC, Liu SW, Chiu H, Lin YJ, Chuang EY, Huang JH, Kao HK, Huang CC*
American Journal of Sports Medicine, 52:406-422 (2024)
The transplantation of 3-dimensional spheroids of adipose-derived stem cells promotes Achilles tendon healing in rabbits by enhancing the proliferation of tenocytes and suppressing M1 macrophages
Chen SH*, Lee YW, Kao HK, Yang PC, Chen SH, Liu SW, Yang PC, Lin YJ, Huang CC*
ACS Nano, 18:18712-18728 (2024)
A self-cascade penetrating brain tumor immunotherapy-mediated by near-infrared-II cell membrane-disrupting nanoflakes via detained dendritic cells
Yalamandala BN, Chen YJ, Lin YH, Huynh TMH, Chiang WH, Chou TC, Liu HW, Huang CC, Lu YJ, Chiang CS, Chu LA, Hu SH*
International Journal of Biological Macromolecules, 283:137764 (2024)
Combining ultrasound technology with targeted fucoidan/arginine-gelatin nanoparticles loaded with doxorubicin to enhance therapeutic efficacy and modulate bioeffects in drug-resistant triple-negative breast cancer
Hsiao CH, Huang HL, Liu HL, Huang CC, Su JC, Chen YH, Lin YS*
International Journal of Biological Macromolecules, 241:124636 (2023)
Aligned core-shell fibrous nerve wrap containing Bletilla striata polysaccharide improves functional outcomes of peripheral nerve repair
Chen SH*, Lien PH, Lin FH, Chou PY, Chen CH, Chen ZY, Chen SH, Hsieh ST, Huang CC, Kao HK*
International Journal of Molecular Science, 23:6322 (2022)
Strontium peroxide-loaded composite scaffolds capable of generating oxygen and modulating behaviors of osteoblasts and osteoclasts
Lin SJ, Huang CC*
Gut, 71:1843-1855 (2022)
Reversal of pancreatic desmoplasia by a tumor stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumors
Huang HC, Sung YC, Li CP, Wan D, Chao PH, Liao BW, Cheng HT, Hsu FF, Huang CC, Liao YH, Hsieh HT, Shih YC, Liu IJ, Wu HC, Lu TT*, Wang J*, Chen Y*
ACS Applied Materials & Interfaces, 14:6343-6357 (2022)
Magnetic-responsive release of nitric oxide from a MOF-derived Fe3O4@PLGA microsphere for the treatment of bacteria-infected cutaneous wound
Chung CW, Liao BW, Huang SW, Chiou SJ, Chang CH, Lin SJ, Chen BH, Liu WL, Hu SH, Chuang YC, Lin CH, Hsu IJ, Cheng CM, Huang CC, Lu TT*
Biomaterials, 272:120765 (2021)
Transplantation of 3D MSC/HUVEC spheroids with neuroprotective and proangiogenic potentials ameliorates ischemic stroke brain injury
Hsu TW, Lu YJ, Lin YJ, Huang YT, Hsieh LH, Wu BH, Lin YC, Chen LC, Wang HW, Chuang JC, Fang YQ, Huang CC*
Advanced Healthcare Materials, 10:2100024 (2021)
Bioactive decellularized extracellular matrix derived from 3D stem cell spheroids under macromolecular crowding serves as a scaffold for tissue engineering
Chiang CE, Fang YC, Ho CT, Assunção M, Lin SJ, Wang YC, Blocki A*, Huang CC*
Bioengineering & Translational Medicine, 6:10212 (2021)
Injection of hybrid 3D spheroids composed of podocytes, mesenchymal stem cells, and vascular endothelial cells into the renal cortex improves kidney function and replenishes glomerular podocytes
Yang WY, Chen LC, Jhuang YT, Lin YJ, Hung PY, Lo YC, Tsai MY, Lee YW, Hsu LW, Yeh CK, Hsu HH*, Huang CC*
Materials Science and Engineering C: Materials for Biological Applications, 120:111753 (2021)
Gelatin scaffold with multifunctional curcumin-loaded lipid-PLGA hybrid microparticles for regenerating corneal endothelium
Lee PC, Chen SC, Hsueh YJ, Shen YC, Tsai MY, Hsu LW, Yeh CK, Chen HC*, Huang CC*
Cells, 10:2747 (2021)
Modulation of inherent niches in 3D multicellular MSC spheroids reconfigures metabolism and enhances therapeutic potential
Chen LC, Wang HW, Huang CC*
International Journal of Molecular Sciences, 22:10101 (2021)
Cell-penetrating delivery of nitric oxide by biocompatible dinitrosyl iron complex and its dermato-physiological implications
Chen YC, Chen YH, Chiu Han, Ko YH, Wang RT, Wang WP, Chuang YJ, Huang CC*, Lu TT*
Biomedicine & Pharmacotherapy, 144:112306 (2021)
Ascorbic acid ameliorates corneal endothelial dysfunction and enhances cell proliferation via the noncanonical GLUT1-ERK axis
Hsueh YJ, Meir YJJ, Lai JY, Huang CC, Lu TT, Ma DHK, Cheng CM, Wu WC, Chen HC*
ACS Applied Materials and Interfaces, 13:38090-38104 (2021)
Robust O2 supplementation from a trimetallic nanozyme-based self-sufficient complementary system synergistically enhances the starvation/photothermal therapy against hypoxic tumors
Wu CY, Hsu YH, Chen Y, Yang LC, Tseng SC, Chen WR, Huang CC, Wan D*
Frontiers in Cell and Developmental Biology, 8:604946 (2020)
3D Spheroids of umbilical cord blood MSC-derived Schwann cells promote peripheral nerve regeneration
Lin YJ, Lee YW, Chang CW, Huang CC*
Frontiers in Bioengineering and Biotechnology, 8:511 (2020)
Optimizing an injectable Composite oxygen-generating system for relieving tissue hypoxia
Hsieh TE, Lin SJ, Chen LC, Chen CC, Lai PL*, Huang CC*
Frontiers in Cell and Developmental Biology, 8:327 (2020)
Development of a novel hanging drop platform for engineering controllable 3D microenvironments
Cho CY, Chiang TH, Hsieh LH, Yang WY, Hsu HH, Yeh CK, Huang CC*, Huang JH*
Advanced Biosystems, 4:1900254 (2020)
Enhancement of subcutaneously transplanted β cell survival using 3D stem cell spheroids with pro-angiogenic & pro-survival potential
Yu CP, Juang JH, Lin YJ, Kuo CW, Hsieh LH, Huang CC*
Cells, 9:943 (2020)
Topical ascorbic acid ameliorates oxidative stress-induced corneal endothelial damage via suppression of apoptosis and autophagic flux blockage
Hsueh YJ, Meir YJJ, Yeh LK, Wang TK, Huang CC, Lu TT, Cheng CM, Wu WC, Chen HC*
Journal of Cellular and Molecular Medicine, 24:6596-6608 (2020)
Lysophosphatidic acid improves corneal endothelial density in tissue culture by stimulating stromal secretion of interleukin-1β
Hsueh YJ, Meir YJJ, Lai JY, Chen HC*, Ma DHK, Huang CC, Lu TT, Cheng CM, Wu WC
World Journal of Clinical Cases, 7:642–649 (2019)
Perioperative topical ascorbic acid for the prevention of phacoemulsification-related corneal endothelial damage: Two case reports and review of literature
Lee CY, Chen HT, Hsueh YJ, Chen HC*, Huang CC, Meir YJJ, Cheng CM, Wu WC