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Publication
Journal Papers
2025
Huang CC*, Chang CK, Yang PC, Chiu H, Chen SH, Hsu LW, “Injectable glucose-releasing microgels enhance the survival and therapeutic potential of transplanted MSCs under ischemic conditions,” Advanced Healthcare Materials, in press.
https://doi.org/10.1002/adhm.202401724
Chen GH, Sia KC, Liu SW, Kao YC, Yang PC, Ho CH, Huang SC, Lee PY, Liang MZ, Chen L, Huang CC*, “Implantation of MSC spheroid-derived 3D decellularized ECM enriched with the MSC secretome ameliorates traumatic brain injury and promotes brain repair,” Biomaterials, vol. 315, pp. 122941, 2025.
https://doi.org/10.1016/j.biomaterials.2024.122941
2024
Chiu H, Chau FA, Chen YH, Koi RX, Yu CK, Hsieh LH, Shyu YM, Amer TAM, Hsueh YJ, Tsao TY, Shen YJ, Wang YM, Chen HC*, Lu YJ*, Huang CC*, Lu TT*, “Mechanistic and kinetic insights into cellular uptake of biomimetic dinitrosyl iron complexes and intracellular delivery of NO for activation of cytoprotective HO-1,” JACS Au, vol. 4, pp. 1550-1569, 2024.
https://doi.org/10.1021/jacsau.4c00064
Chen SH*, Wang HW, Yang PC, Chen SH, Ho CH, Yang PC, Kao YC, Liu SW, Chiu H, Lin YJ, Chuang EY, Huang JH, Kao HK, Huang CC*, “Schwann cells acquire a repair phenotype after assembling into spheroids and show enhanced in vivo therapeutic potential for promoting peripheral nerve repair,” Bioengineering & Translational Medicine, vol. 9, pp.e10635, 2024.
https://doi.org/10.1002/btm2.10635
Chen SH*, Lee YW, Kao HK, Yang PC, Chen SH, Liu SW, Yang PC, Lin YJ, Huang CC*, “The transplantation of 3-dimensional spheroids of adipose-derived stem cells promotes Achilles tendon healing in rabbits by enhancing the proliferation of tenocytes and suppressing M1 macrophages,” American Journal of Sports Medicine, vol. 52, pp.406-422, 2024.
https://doi.org/10.1177/03635465231214698
Yalamandala BN, Chen YJ, Lin YH, Huynh TMH, Chiang WH, Chou TC, Liu HW, Huang CC, Lu YJ, Chiang CS, Chu LA, Hu SH*, “A self-cascade penetrating brain tumor immunotherapy-mediated by near-infrared-II cell membrane-disrupting nanoflakes via detained dendritic cells,” ACS Nano, vol. 18, pp. 18712-18728, 2024.
https://doi.org/10.1021/acsnano.4c06183
Hsiao CH, Huang HL, Liu HL, Huang CC, Su JC, Chen YH, Lin YS*, “Combining ultrasound technology with targeted fucoidan/arginine-gelatin nanoparticles loaded with doxorubicin to enhance therapeutic efficacy and modulate bioeffects in drug-resistant triple-negative breast cancer,” International Journal of Biological Macromolecules, vol. 283, pp. 137764, 2024.
https://doi.org/10.1016/j.ijbiomac.2024.137764
2023
Chen SH, Lien PH, Lin FH, Chou PY, Chen CH, Chen ZY, Chen SH, Hsieh ST, Huang CC, Kao HK, “Aligned core-shell fibrous nerve wrap containing Bletilla striata polysaccharide improves functional outcomes of peripheral nerve repair,” International Journal of Biological Macromolecules, vol. 241, pp.124636, 2023.
https://doi.org/10.1016/j.ijbiomac.2023.124636
2022
Lin SJ, Huang CC*, “Strontium peroxide-loaded composite scaffolds capable of generating oxygen and modulating behaviors of osteoblasts and osteoclasts,” International Journal of Molecular Science, vol. 23, 6322, 2022.
https://doi.org/10.3390/ijms23116322
Huang HC, Sung YC, Li CP, Wan D, Chao PH, Liao BW, Cheng HT, Hsu FF, Huang CC, Liao YH, Hsieh HT, Shih YC, Liu IJ, Wu HC, Lu TT*, Wang J*, Chen Y*, “Reversal of pancreatic desmoplasia by a tumor stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumors,” Gut, vol. 71, 1843-1855, 2022.
https://doi.org/10.1136/gutjnl-2021-325180
Chung CW, Liao BW, Huang SW, Chiou SJ, Chang CH, Lin SJ, Chen BH, Liu WL, Hu SH, Chuang YC, Lin CH, Hsu IJ, Cheng CM, Huang CC, Lu TT*, “Magnetic-responsive release of nitric oxide from a MOF-derived Fe3O4@PLGA microsphere for the treatment of bacteria-infected cutaneous wound,” ACS Applied Materials & Interfaces, vol. 14, 6343-6357, 2022.
https://doi.org/10.1021/acsami.1c20802
2021
Hsu TW, Lu YJ, Lin YJ, Huang YT, Hsieh LH, Wu BH, Lin YC, Chen LC, Wang HW, Chuang JC, Fang YQ, Huang CC*, “Transplantation of 3D MSC/HUVEC spheroids with neuroprotective and proangiogenic potentials ameliorates ischemic stroke brain injury,” Biomaterials, vol. 272, 120765, 2021.
https://doi.org/10.1016/j.biomaterials.2021.120765
Chiang CE, Fang YC, Ho CT, Assunção M, Lin SJ, Wang YC, Blocki A*, Huang CC*, “Bioactive decellularized extracellular matrix derived from 3D stem cell spheroids under macromolecular crowding serves as a scaffold for tissue engineering,” Advanced Healthcare Materials, vol. 10, 2100024, 2021.
https://doi.org/10.1002/adhm.202100024
Yang WY, Chen LC, Jhuang YT, Lin YJ, Hung PY, Lo YC, Tsai MY, Lee YW, Hsu LW, Yeh CK, Hsu HH*, Huang CC*, “Injection of hybrid 3D spheroids composed of podocytes, mesenchymal stem cells, and vascular endothelial cells into the renal cortex improves kidney function and replenishes glomerular podocytes,” Bioengineering & Translational Medicine, e10212, 2021.
https://doi.org/10.1002/btm2.10212
Lee PC, Chen SC, Hsueh YJ, Shen YC, Tsai MY, Hsu LW, Yeh CK, Chen HC*, Huang CC*, “Gelatin scaffold with multifunctional curcumin-loaded lipid-PLGA hybrid microparticles for regenerating corneal endothelium,” Materials Science and Engineering C: Materials for Biological Applications, vol. 120, 111753, 2021.
https://doi.org/10.1016/j.msec.2020.111753
Chen LC, Wang HW, Huang CC*, “Modulation of inherent niches in 3D multicellular MSC spheroids reconfigures metabolism and enhances therapeutic potential,” Cells, vol. 10, 2747, 2021.
https://doi.org/10.3390/cells10102747
Chen YC, Chen YH, Chiu Han, Ko YH, Wang RT, Wang WP, Chuang YJ, Huang CC*, Lu TT*, “Cell-penetrating delivery of nitric oxide by biocompatible dinitrosyl iron complex and its dermato-physiological implications,” International Journal of Molecular Sciences, vol. 22, 10101, 2021.
https://doi.org/10.3390/ijms221810101
Hsueh YJ, Meir YJJ, Lai JY, Huang CC, Lu TT, Ma DHK, Cheng CM, Wu WC, Chen HC*, “Ascorbic acid ameliorates corneal endothelial dysfunction and enhances cell proliferation via the noncanonical GLUT1-ERK axis,” Biomedicine & Pharmacotherapy, vol. 144, 112306, 2021.
https://doi.org/10.1016/j.biopha.2021.112306
Wu CY, Hsu YH, Chen Y, Yang LC, Tseng SC, Chen WR, Huang CC, Wan D*, “Robust O2 supplementation from a trimetallic nanozyme-based self-sufficient complementary system synergistically enhances the starvation/photothermal therapy against hypoxic tumors,” ACS Applied Materials and Interfaces, vol. 13, 38090-38104, 2021.
https://doi.org/10.1021/acsami.1c10656
2020
Lin YJ, Lee YW, Chang CW, Huang CC*, “3D Spheroids of umbilical cord blood MSC-derived Schwann cells promote peripheral nerve regeneration,” Frontiers in Cell and Developmental Biology, vol. 8, 604946, 2020.
https://doi.org/10.3389/fcell.2020.604946
Hsieh TE, Lin SJ, Chen LC, Chen CC, Lai PL*, Huang CC*,“Optimizing an injectable Composite oxygen-generating system for relieving tissue hypoxia,” Frontiers in Bioengineering and Biotechnology, vol. 8, 511, 2020.
https://doi.org/10.3389/fbioe.2020.00511
Cho CY, Chiang TH, Hsieh LH, Yang WY, Hsu HH, Yeh CK, Huang CC*, Huang JH*, “Development of a novel hanging drop platform for engineering controllable 3D microenvironments,” Frontiers in Cell and Developmental Biology, vol. 8, 327, 2020.
https://doi.org/10.3389/fcell.2020.00327
Yu CP, Juang JH, Lin YJ, Kuo CW, Hsieh LH, Huang CC*, “Enhancement of subcutaneously transplanted β cell survival using 3D stem cell spheroids with pro-angiogenic & pro-survival potential,” Advanced Biosystems, vol. 4, 1900254, 2020 (selected as cover image).
https://doi.org/10.1002/adbi.201900254
Hsueh YJ, Meir YJJ, Yeh LK, Wang TK, Huang CC, Lu TT, Cheng CM, Wu WC, Chen HC,* “Topical ascorbic acid ameliorates oxidative stress-induced corneal endothelial damage via suppression of apoptosis and autophagic flux blockage,“ Cells, vol. 9, 943, 2020.
https://doi.org/10.3390/cells9040943
Hsueh YJ, Meir YJJ, Lai JY, Chen HC*, Ma DHK, Huang CC, Lu TT, Cheng CM, Wu WC, “Lysophosphatidic acid improves corneal endothelial density in tissue culture by stimulating stromal secretion of interleukin-1β,“ Journal of Cellular and Molecular Medicine, vol. 24, 6596-6608, 2020.
https://doi.org/10.1111/jcmm.15307
2019
Lee CY, Chen HT, Hsueh YJ, Chen HC*, Huang CC, Meir YJJ, Cheng CM, Wu WC, “Perioperative topical ascorbic acid for the prevention of phacoemulsification-related corneal endothelial damage: Two case reports and review of literature,” World Journal of Clinical Cases, vol. 7, 642–649, 2019.
Before independent research career
2017
Wan WL, Lin YJ, Chen HL, Huang CC, Shih PC, Bow YR, Chia WT, Sung HW*, “In situ nanoreactor for photosynthesizing H2 gas to mitigate oxidative stress in tissue inflammation,” Journal of the American Chemical Society, vol.139, 12923–12926, 2017.
Lin WC†, Huang CC†, Lin SJ, Lu CW, Liu CK, Lin YJ, Li MJ*, Sung HW*, “In situ depot that mimics endogenous production of a gasotransmitter hydrogen sulfide for treating diabetic wounds,” Biomaterials, vol.145, 1−8, 2017. (†Co-first author)
Lin YJ†, Huang CC†, Wan WL, Chiang CH, Sung HW*, “Recent advances in CO2 bubble-generating carrier systems for localized controlled release,” Biomaterials, vol.133, 154−164, 2017. (†Co-first author)
Korupalli C†, Huang CC†, Lin WC, Pan WY, Lin PY, Wan WL, Li MJ, Chang Y*, Sung HW*, “Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection,” Biomaterials, vol.116, 1−9, 2017. (†Co-first author)
2016
Huang CC, Liao ZX, Lu HM, Pan WY, Wan WL, Chen CH, Sung HW*, “Cellular organelle-dependent cytotoxicity of iron oxide nanoparticles and its implications for cancer diagnosis and treatment: a mechanistic investigation,” Chemistry of Materials, vol. 28, 9017–9025, 2016.
Pan WY†, Lin KJ†, Huang CC†, Chiang WL, Lin YJ, Lin WC, Chuang EY, Chang Y*, Sung HW*, “Localized sequence-specific release of a chemopreventive agent and an anticancer drug in a time-controllable manner to enhance therapeutic efficacy,” Biomaterials, vol.101, 241−250, 2016. (†Co-first author)
Huang CC, Chia WT, Chung MF, Lin KJ, Hsiao CW, Jin C, Lim WH, Chen CC, Sung HW*, “An implantable depot that can generate oxygen in situ for overcoming hypoxia-induced resistance to anticancer drugs in chemotherapy,” Journal of the American Chemical Society, vol.138, 5222–5225, 2016.
Pan WY†, Huang CC†, Lin TT, Hu HY, Lin WC, Li MJ, Sung HW*, “Synergistic antibacterial effects of localized heat and oxidative stress caused by hydroxyl radicals mediated by graphene/iron oxide-based nanocomposites,” Nanomedicine: Nanotechnology, Biology and Medicine, vol.12, 431–438, 2016. (†Co-first author)
Huang CC, Pan WY, Tseng M T, Lin KJ, Yang YP, Tsai HW, Hwang SM, Chang Y, Wei HJ*, Sung HW*, “Enhancement of cell adhesion, retention, and survival of cell aggregates transplanted in ischemic tissues by concurrent delivery of an antioxidant for therapeutic angiogenesis,” Biomaterials, vol.74, 53−63, 2016.
2015
Huang CC, Wei HJ, Lin KJ, Lin WW, Wang CW, Pan WY, Hwang SM, Chang Y*, Sung HW*, “Multimodality noninvasive imaging of therapeutic effects of exogenously transplanted cell aggregates capable of angiogenesis on acute myocardial infarction,” Biomaterials, vol.73, 12−22, 2015.
This paper is honored as a recipient of Elsevier 2015 Biomaterials Outstanding Paper Award
2014
Huang CC, Liao ZX, Chen DY, Hsiao CW, Chang Y*, Sung HW*, “Injectable Cell Constructs Fabricated via Culture on a Thermo-Responsive Methylcellulose Hydrogel System for the Treatment of Ischemic Diseases,” Advanced Healthcare Materials, vol.3, 1133−1148, 2014.
2013
Huang CC, Chen DY, Wei HJ, Lin KJ, Wu CT, Lee TY, Hu HY, Hwang SM, Chang Y*, Sung HW.*, “Hypoxia-induced therapeutic neovascularization in a mouse model of an ischemic limb using cell aggregates composed of HUVECs and cbMSCs,” Biomaterials, vol.34, 9441−9450, 2013.
Chen DY, Wei HJ, Lin WW, Lin KJ, Huang CC, Wu CT, Hwang SM, Chang Y*, Sung HW*, “Intramuscular delivery of 3D aggregates of HUVECs and cbMSCs for cellular cardiomyoplasty in rats with myocardial infarction,” Journal of Controlled Release, vol.172, 419−425, 2013
Huang CC, Tsai HW, Lee WY, Lin WW, Chen DY, Hung YW, Chen JW, Hwang SM, Chang Y*, Sung HW*, “A translational approach in using cell sheet fragments of autologous bone marrow-derived mesenchymal stem cells for cellular cardiomyoplasty in a porcine model,” Biomaterials, vol.34, 4582−4591, 2013.
Chen DY, Wei HJ, Lin KJ, Huang CC, Wang CC, Wu CT, Chao KT, Chen KJ, Chang Y*, Sung HW*, “Three-dimensional cell aggregates composed of HUVECs and cbMSCs for therapeutic neovascularization in a mouse model of hindlimb ischemia,” Biomaterials, vol.34, 1995−2004, 2013.
2012
Huang CC, Wei HJ, Yeh YC, Wang JJ, Lin WW, Lee TY, Hwang SM, Choi SW, Xia Y, Chang Y*, Sung HW*, “Injectable PLGA porous beads cellularized by hAFSCs for cellular cardiomyoplasty,” Biomaterials, vol.33, 4069−4077, 2012.
Lee WY, Wei HJ, Wang JJ, Lin KJ, Lin WW, Chen DY, Huang CC, Lee TY, Ma HY, Hwang SM, Chang Y*, Sung HW*, “Vascularization and restoration of heart function in rat myocardial infarction using transplantation of human cbMSC/HUVEC core-shell bodies,” Biomaterials, vol.33, 2127−2136, 2012.
2010
Huang CC, Liao CK, Yang MJ, Chen CH, Hwang SM, Hung YW, Chang Y*, Sung HW*, “A strategy for fabrication of a three-dimensional tissue construct containing uniformly distributed embryoid body-derived cells as a cardiac patch,” Biomaterials, vol.31, 6218−6227, 2010.
2009
Lee WY, Chang YH, Yeh YC, Chen CH, Lin K M, Huang CC, Chang Y*, Sung HW*, “The use of injectable spherically symmetric cell aggregates self-assembled in a thermo-responsive hydrogel for enhanced cell transplantation,” Biomaterials, vol.30, 5505−5513, 2009.
2008
Wei HJ, Chen CH, Lee WY, Chiu I, Hwang SM, Lin WW, Huang CC, Yeh YC, Chang Y*, Sung HW*, “Bioengineered cardiac patch constructed from multilayered mesenchymal stem cells for myocardial repair,” Biomaterials, vol.29, 3547−3556, 2008.
2007
Chen CH, Chang Y, Wang CC, Huang CH, Huang CC, Yeh YC, Hwang SM, Sung HW*, “Construction and characterization of fragmented mesenchymal-stem-cell sheets for intramuscular injection,” Biomaterials, vol.28, 4643−4651, 2007.
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